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Cerebral stiffness changes during visual stimulation: Differential physiological mechanisms characterized by opposing mechanical effects
- Source :
- Neuroimage: Reports, Vol 1, Iss 2, Pp 100014- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- We performed functional intrinsic Magnetic Resonance Elastography (fiMRE) as well as Time of Flight angiography and BOLD fMRI on 7 healthy human subjects to monitor shear stiffness and arterial dilation during periods of prolonged visual stimulation. FiMRE activation with increased stiffness was observed to occur almost equally within brain white and gray matter (49.7±14.0% and 40.9±12.2%, respectively), while activation with decreased stiffness was significantly (p=0.018) more likely to occur in white matter than gray matter (50.8±11.4% and 37.0±4.5%, respectively). At the low mechanical activation and block design frequencies used in this intrinsic MRE (iMRE) approach, the aggregate stiffness change across the entire BOLD activation region was not significant. However, we observed significant reduction in shear stiffness (1.40 ± 0.15 to 0.68 ± 0.22 [kPa], p
Details
- Language :
- English
- ISSN :
- 26669560
- Volume :
- 1
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Neuroimage: Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f4a4b317ad5b41f7af7917a260964032
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ynirp.2021.100014