PRECLINICAL STUDY OF PHARMACOLOGICAL ACTIVITY OF ENTEROSORBENTE ON THE BASIS OF MONTMORILLONITE

Introduction: At present, enterosorbents based on mineral raw materials are in high demand among the population. However, there are no enterosorbents on the Russian pharmaceutical market on the basis of domestic mineral raw materials. Objectives: to study the pharmacological activity of enterosorbent based on montmorillonite of Russian origin under experimental conditions. Methods: The methodological approach was based on the implementation of a complex of theoretical, pharmacological, toxicological, histological, biochemical, statistical methods. Models of experimental diarrhea, acute and toxic liver damage, acute experimental pancreatitis were selected. Results and discussion: Enterosorbent based on montmorillonite Crim_04 has a dose-dependent antidiarrhoeal effect, which is manifested in an increase in the time of onset of diarrhea from 50.4% to 82.6% with various models of diarrhea, a reduction in the number of defecations from 50.4% to 64.4% liquid in them. Enterosorbent on the basis of montmorillonite has a high sorption activity to E.coli enterotoxin, inhibiting the outflow of fluid into the luminal cavity by 95.1%. In addition, the use of enterosorbent Crim_04 significantly improves biochemical indices in the blood serum of rats when modeling acute and chronic liver damage and acute pancreatitis. Conclusion: The enterosorbent under the Crim_04 cipher has a dose-dependent anti-diarrhea, detoxification activity, high sorption activity for E.coli enterotoxin, high therapeutic efficacy in experimental pancreatitis, most pronounced at a dose of 3320 mg / kg. It can be recommended for further complex toxicological studies and clinical trials.