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Crystal structure of 3-{5-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-1H-pyrazol-1-yl}indolin-2-one ethanol monosolvate

Crystal structure of 3-{5-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-1H-pyrazol-1-yl}indolin-2-one ethanol monosolvate

Authors :
Md. Lutfor Rahman
Ajaykumar D. Kulkarni
Mashitah Mohd. Yusoff
Huey Chong Kwong
Ching Kheng Quah
Source :
Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 3, Pp 283-286 (2016)
Publication Year :
2016
Publisher :
International Union of Crystallography, 2016.

Abstract

The title indolin-2-one compound, C28H23FN4O·C2H6O, crystallizes as a 1:1 ethanol solvate. The ethanol molecule is disordered over two positions with refined site occupancies of 0.560 (14) and 0.440 (14). The pyrazole ring makes dihedral angles of 84.16 (10) and 85.33 (9)° with the indolin-2-one and indole rings, respectively, whereas the dihedral angle between indolin-2-one and indole rings is 57.30 (7)°. In the crystal, the components are linked by N—H...O and O—H...O hydrogen bonds, forming an inversion molecule–solvate 2:2 dimer with R44(12) ring motifs. The crystal structure is consolidated by π–π interaction between pairs of inversion-related indolin-2-one rings [interplanar spacing = 3.599 (2) Å].

Details

Language :
English
ISSN :
20569890
Volume :
72
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Acta Crystallographica Section E: Crystallographic Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f562db8c625e4f49b9f3b4d267334a7f
Document Type :
article
Full Text :
https://doi.org/10.1107/S2056989016001614