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Association of HLA alleles with autism
- Source :
- Neuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3259-3265 (2018)
- Publication Year :
- 2018
- Publisher :
- Dove Medical Press, 2018.
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Abstract
- Arezou Sayad,1 Mohammad Taghi Akbari,2 Rezvan Noroozi,3 Mir Davood Omrani,1,4 Hidetoshi Inoko,5 Mohammad Taheri,6 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; 3Photochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 5Department of Molecular Life Science, Tokai University, Hiratsuka, Japan; 6Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran Background: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis. Methods: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls. Results: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population. Conclusion: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis. Keywords: autism, HLA typing, immune response
Details
- Language :
- English
- ISSN :
- 11782021
- Volume :
- ume 14
- Database :
- Directory of Open Access Journals
- Journal :
- Neuropsychiatric Disease and Treatment
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f6862e4c93b4f718863d78bb82791ff
- Document Type :
- article