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Effect of YangxueJiedu Decoction on the expression levels of IL-36 in psoriasis-like lesions in mice
- Source :
- Pifu-xingbing zhenliaoxue zazhi, Vol 28, Iss 3, Pp 164-169 (2021)
- Publication Year :
- 2021
- Publisher :
- editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology, 2021.
-
Abstract
- Objective: To explore the effect of YangxueJiedu decoction on IL-36 expression in a mouse model of imiquimod-induced psoriasis-like lesions. Methods: Eighteen mice were randomly divided into the control, model and experimental groups, with 6 mice per group. The psoriasis severity was assessed by PASI score. The expression levels of mRNA for IL-36α, IL-36β, IL-36γ, and IL-36Ra were measured by RT-qPCR. Expression levels of IL-36β protein were evaluated by both Western blot and immunohistochemistry. Results: PASI scores were significantly lower in experimental group than in the model group (1.17±0.37 vs 7.83±0.69, t=19.07, P
- Subjects :
- psoriasis
mouse
yangxuejiedu decoction
il-36
Dermatology
RL1-803
Subjects
Details
- Language :
- Chinese
- ISSN :
- 16748468
- Volume :
- 28
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Pifu-xingbing zhenliaoxue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f6f5efcd6724415c84c4a342ec6a152f
- Document Type :
- article
- Full Text :
- https://doi.org/10.3969/j.issn.1674-8468.2021.03.002