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Analgesic effects of medicinal plants and phytochemicals on chemotherapy‐induced neuropathic pain through glial modulation

Authors :
Ji Hwan Lee
Nari Kim
Sangwon Park
Sun Kwang Kim
Source :
Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

Abstract Chemotherapy‐induced peripheral neuropathy (CIPN) frequently occurs in cancer patients. This side effect lowers the quality of life of patients and may cause the patients to abandon chemotherapy. Several medications (e.g., duloxetine and gabapentin) are recommended as remedies to treat CIPN; however, usage of these drugs is limited because of low efficacy or side effects such as dizziness, nausea, somnolence, and vomiting. From ancient East Asia, the decoction of medicinal herbal formulas or single herbs have been used to treat pain and could serve as alternative therapeutic option. Recently, the analgesic potency of medicinal plants and their phytochemicals on CIPN has been reported, and a majority of their effects have been shown to be mediated by glial modulation. In this review, we summarize the analgesic efficacy of medicinal plants and their phytochemicals, and discuss their possible mechanisms focusing on glial modulation in animal studies.

Details

Language :
English
ISSN :
20521707
Volume :
9
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Pharmacology Research & Perspectives
Publication Type :
Academic Journal
Accession number :
edsdoj.f7eaec5971c849aa82658c0159d3444c
Document Type :
article
Full Text :
https://doi.org/10.1002/prp2.819