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Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

Authors :
Kotaro Kiga
Xin-Ee Tan
Rodrigo Ibarra-Chávez
Shinya Watanabe
Yoshifumi Aiba
Yusuke Sato’o
Feng-Yu Li
Teppei Sasahara
Bintao Cui
Moriyuki Kawauchi
Tanit Boonsiri
Kanate Thitiananpakorn
Yusuke Taki
Aa Haeruman Azam
Masato Suzuki
José R. Penadés
Longzhu Cui
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f87529d3a0c642c78aab97a22b66d12b
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-16731-6