Back to Search Start Over

Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people

Authors :
Etienne Ojardias
Mélanie Leman
Ludovic Lafaie
Philippe Oriol
Paul Calmels
Thomas Celarier
Source :
The Aging Male, Vol 28, Iss 1 (2025)
Publication Year :
2025
Publisher :
Taylor & Francis Group, 2025.

Abstract

Objective to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.Case presentation We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations. Biological tests excluded primary or hyperparathyroidism and malignancy-related hyperparathyroidism, confirming the diagnosis of FHH through the detection of an inhibitory mutation in the calcium-sensing receptor gene.Conclusion This case suggests to clinicians the possibility of FHH in older patients with unexplained hypercalcemia. In geriatric patients, the diagnosis is complicated because of the poly-pathology: here hypercalcemia was associated with a confusing gout crisis, which was triggered by diuretic treatment for heart failure.

Details

Language :
English
ISSN :
13685538 and 14730790
Volume :
28
Issue :
1
Database :
Directory of Open Access Journals
Journal :
The Aging Male
Publication Type :
Academic Journal
Accession number :
edsdoj.f8cc40454e094f67b8a957a670e0ce4f
Document Type :
article
Full Text :
https://doi.org/10.1080/13685538.2024.2436877