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Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide
- Source :
- International Journal of Endocrinology, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Previous studies showed associations between variants in TCF7L2 gene and the therapeutic response to sulfonylureas. All sulfonylureas stimulate insulin secretion by the closure of ATP-sensitive potassium (KATP) channel. The aim of the present study was to compare TCF7L2 genotype specific effect of gliclazide binding to KATP channel A-site (Group 1) with sulfonylureas binding to AB-site (Group 2). A total of 101 patients were treated with sulfonylureas for 6 months as an add-on therapy to the previous metformin treatment. TCF7L2 rs7903146 C/T genotype was identified by real-time PCR with subsequent melting curve analysis. Analyses using the dominant genetic model showed significantly higher effect of gliclazide in the CC genotype group in comparison with combined CT + TT genotype group (1.32±0.15% versus 0.73±0.11%, Padj=0.005). No significant difference in ΔHbA1c between the patients with CC genotype and the T-allele carriers was observed in Group 2. In the multivariate analysis, only the TCF7L2 genotype (P=0.006) and the baseline HbA1c (P
- Subjects :
- Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Subjects
Details
- Language :
- English
- ISSN :
- 16878337 and 16878345
- Volume :
- 2013
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f8ee17fde8c147c5a382f6cfbc3731b5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2013/374858