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Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the fusion gene: a case report
- Source :
- Journal of International Medical Research, Vol 46 (2018)
- Publication Year :
- 2018
- Publisher :
- SAGE Publishing, 2018.
-
Abstract
- Inflammatory myofibroblastic tumors (IMTs) are neoplasms with low malignant potential, and the most common tumor in the lung and orbit. Their occurrence in the uterus is rare. Approximately 50% of IMT patients have anaplastic lymphoma kinase gene ( ALK ) rearrangements. Recent studies described novel fusions involving ROS1 , platelet-derived growth factor receptor beta ( PDGFR-β ), and ETS translocation variant ( ETV6 ) genes in a subset of ALK -negative patients. We report a 44-year-old woman with anemia and uterine IMT. Ultrasonography and magnetic resonance imaging revealed a myxoid degenerative myoma-like mass, 7.4 cm in maximum diameter, on the left uterine side wall. Hysterectomy was performed as a definitive treatment. Microscopic examination revealed spindle cell proliferation with numerous lymphocytes and plasma cells. Immunohistochemically, the spindle cells were negative for ALK-1, desmin, and smooth muscle actin. The pathological diagnosis was IMT arising from the uterus. Fluorescence in situ hybridization demonstrated an ETV6– neurotrophic tyrosine kinase, receptor, type 3 gene ( NTRK3 ) translocation but no ALK , ROS1 , or PDGFR-β translocations. Lung and abdomen computed tomography at 31 months postoperatively revealed no disease recurrence. This association of an ETV6–NTRK3 fusion oncogene with an ALK -negative uterine IMT increases our understanding of this neoplasm, which may help the development of specific therapies.
- Subjects :
- Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 03000605 and 14732300
- Volume :
- 46
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of International Medical Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f8f22e1e7d5347369ea6685b16be4ee8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1177/0300060518780873