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What Can the Gut Microbiota of Animals Teach Us about the Relationship between Nutrition and Burden of Lifestyle Diseases?

Authors :
Denise Mafra
Natália A. Borges
Beatriz G. Baptista
Layla F. Martins
Gillian Borland
Paul G. Shiels
Peter Stenvinkel
Source :
Nutrients, Vol 16, Iss 11, p 1789 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The gut microbiota performs several crucial roles in a holobiont with its host, including immune regulation, nutrient absorption, synthesis, and defense against external pathogens, significantly influencing host physiology. Disruption of the gut microbiota has been linked to various chronic conditions, including cardiovascular, kidney, liver, respiratory, and intestinal diseases. Studying how animals adapt their gut microbiota across their life course at different life stages and under the dynamics of extreme environmental conditions can provide valuable insights from the natural world into how the microbiota modulates host biology, with a view to translating these into treatments or preventative measures for human diseases. By modulating the gut microbiota, opportunities to address many complications associated with chronic diseases appear. Such a biomimetic approach holds promise for exploring new strategies in healthcare and disease management.

Details

Language :
English
ISSN :
20726643
Volume :
16
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.f92ff1a0fd0748fb9259ac3324f51d7f
Document Type :
article
Full Text :
https://doi.org/10.3390/nu16111789