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Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia: The REAP-AP study

Authors :
Yong Chon Park
Min-Soo Lee
Tian-Mei Si
Helen F.K. Chiu
Shigenobu Kanba
Mian-Yoon Chong
Adarsh Tripathi
Pichet Udomratn
Kok Yoon Chee
Andi J. Tanra
Golam Rabbani
Afzal Javed
Samudra Kathiarachchi
Win Aung Myint
Tran Van Cuong
Kang Sim
Shu-yu Yang
Norman Sartorius
Chay-Hoon Tan
Naotaka Shinfuku
Seon-Cheol Park
Source :
Saudi Pharmaceutical Journal, Vol 27, Iss 2, Pp 246-253 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P

Subjects

Subjects :
Therapeutics. Pharmacology
RM1-950

Details

Language :
English
ISSN :
13190164
Volume :
27
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Saudi Pharmaceutical Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.f9c6e7527c9742be86dfa6e64f715dfc
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jsps.2018.11.006