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A primary mediastinal germ cell tumor of yolk sac type: case report

Authors :
Khadija Darif
Zineb Benbrahim
Nisrine Acharfi
Anass Khacha
Mustapha Maaroufi
Lamiae Amaadour
Karima Oualla
Samia Arifi
Nawfel Mellas
Source :
The Pan African Medical Journal, Vol 38, Iss 330 (2021)
Publication Year :
2021
Publisher :
The Pan African Medical Journal, 2021.

Abstract

The mediastinal malignant germ cells tumor represent less than 0.5% of thoracic tumors, although the mediastinum is one of the main extragonadic locations of these tumors. In the majority of cases, young people are those most affected. The prognosis of mediastinal malignant germ cells tumors is poor, especially non-seminomatous germ tumors. In this article, we report a rare case of a young 19-years-old patient treated for a mediastinal germ cell tumor of yolk sac. The patient presented a chest pain; the chest CT showed a right paramedian mediastinal mass with a pleural effusion associated with supraclavicular and cervical lymph nodes. Biopsy revealed a non-seminomatousgerm cell tumor of yolk sac. The exams showed elevated alpha-fetoprotein (AFP), without any meaningful elevation of other serictumor markers. The patient received 4 cycles of chemotherapy based on etoposide, ifosfamide and platinum salts then a complete excision of the mass.

Details

Language :
English, French
ISSN :
19378688
Volume :
38
Issue :
330
Database :
Directory of Open Access Journals
Journal :
The Pan African Medical Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.f9f24428c44fcaae097b61c079bdde
Document Type :
article
Full Text :
https://doi.org/10.11604/pamj.2021.38.330.23730