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The Mitochondrial Connection: The Nek Kinases’ New Functional Axis in Mitochondrial Homeostasis

Authors :
Fernanda L. Basei
Ivan Rosa e Silva
Pedro R. Firmino Dias
Camila C. Ferezin
Andressa Peres de Oliveira
Luidy K. Issayama
Livia A. R. Moura
Fernando Riback da Silva
Jörg Kobarg
Source :
Cells, Vol 13, Iss 6, p 473 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Mitochondria provide energy for all cellular processes, including reactions associated with cell cycle progression, DNA damage repair, and cilia formation. Moreover, mitochondria participate in cell fate decisions between death and survival. Nek family members have already been implicated in DNA damage response, cilia formation, cell death, and cell cycle control. Here, we discuss the role of several Nek family members, namely Nek1, Nek4, Nek5, Nek6, and Nek10, which are not exclusively dedicated to cell cycle-related functions, in controlling mitochondrial functions. Specifically, we review the function of these Neks in mitochondrial respiration and dynamics, mtDNA maintenance, stress response, and cell death. Finally, we discuss the interplay of other cell cycle kinases in mitochondrial function and vice versa. Nek1, Nek5, and Nek6 are connected to the stress response, including ROS control, mtDNA repair, autophagy, and apoptosis. Nek4, in turn, seems to be related to mitochondrial dynamics, while Nek10 is involved with mitochondrial metabolism. Here, we propose that the participation of Neks in mitochondrial roles is a new functional axis for the Nek family.

Details

Language :
English
ISSN :
13060473 and 20734409
Volume :
13
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.f9ff3481ef8b4b78a60aae8d2123e7c1
Document Type :
article
Full Text :
https://doi.org/10.3390/cells13060473