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Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy

Authors :
Lauren L. Jantzie
Akosua Y. Oppong
Fatu S. Conteh
Tracylyn R. Yellowhair
Joshua Kim
Gabrielle Fink
Adam R. Wolin
Frances J. Northington
Shenandoah Robinson
Source :
Frontiers in Neurology, Vol 9 (2018)
Publication Year :
2018
Publisher :
Frontiers Media S.A., 2018.

Abstract

Cerebral palsy (CP) is the leading cause of motor impairment for children worldwide and results from perinatal brain injury (PBI). To test novel therapeutics to mitigate deficits from PBI, we developed a rat model of extreme preterm birth (

Details

Language :
English
ISSN :
16642295
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Frontiers in Neurology
Publication Type :
Academic Journal
Accession number :
edsdoj.fa4c3f3412bd419b8f45bb92151d3da8
Document Type :
article
Full Text :
https://doi.org/10.3389/fneur.2018.00233