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A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs

Authors :
Georgina B. F. Hall
Rachael Birkbeck
Benjamin M. Brainard
Fernanda Camacho
Elizabeth B. Davidow
Dana N. LeVine
Andrew Mackin
Taylor Moss
Katherine J. Nash
Giacomo Stanzani
Daria Starybrat
David Q. Stoye
Carolyn Tai
John Thomason
Julie M. Walker
K. Jane Wardrop
Helen Wilson
Virginie A. Wurlod
Karen Humm
Source :
Journal of Veterinary Internal Medicine, Vol 38, Iss 5, Pp 2495-2506 (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Abstract Background Reported incidence of blood transfusion reactions (TR) varies greatly. Objective To prospectively evaluate the incidence of acute TRs in dogs receiving allogenic blood products, using consensus definitions, and to assess factors associated with TRs. Animals Dogs (n = 858) administered allogenic blood products (n = 1542) between March and November 2022. Methods Prospective, multicenter surveillance study occurring in referral hospitals in the United States, United Kingdom, and Australia recording TRs in dogs administered blood products as defined by the consensus guidelines published by The Association of Veterinary Hematology and Transfusion Medicine in 2021. Results The incidence of acute TR was 8.9% (95% CI 7.0‐11.1) for packed red blood cells (pRBCs) and 4.5% (95% CI 2.9‐6.6) for plasma products. The most frequently reported TRs were febrile nonhemolytic TRs (FNHTR; 4%, 95% CI 2.8‐5.5) when administering pRBCs and allergic TRs (3.2%, 95% CI 1.80‐5.10) when administering plasma products. A higher dose of pRBC (adjusted odds ratio [aOR] 1.04 [95% CI 1.00‐1.08]) was associated with a higher odds of TR. Administration of pRBCs stored for longer than 28 days was associated with higher odds of FNHTR (aOR 4.10 [95% CI 1.58‐10.65]) and acute hemolytic TR (AHTR; OR 15.2 [95% CI 3.35‐68.70]) when compared with pRBCs stored for 14 days or fewer. Leukoreduction of pRBC was not associated with lower odds of developing a TR (OR 1.47 [95% CI 0.89‐2.42]). Conclusions and Clinical Importance Clinicians should be mindful of the age and dose of pRBC prescribed to dogs.

Details

Language :
English
ISSN :
19391676 and 08916640
Volume :
38
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Journal of Veterinary Internal Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.fa536a4ec50a47b1bbf67a6e84e846b7
Document Type :
article
Full Text :
https://doi.org/10.1111/jvim.17175