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[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- The link between amyloid and tau proteins with Alzheimer’s disease progression remains unclear. Here, the authors propose HDACs I downregulation as an element linking the deleterious effects of brain proteinopathies with disease progression.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fa6fec43d93b4296b1333a2f0ecd7e12
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-30653-5