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FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Forkhead box transcription factor, FOXQ1 is reported to promote epithelial-mesenchymal transition (EMT) and cancer metastasis. Here the authors show that FOXQ1 recruits the KMT2/MLL histone methyltransferase complex as a transcriptional coactivator to activate EMT programme in breast cancer.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fb2c929fd9f444428d14613bbb55b90c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-34239-z