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Association between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations
- Source :
- Hereditas, Vol 158, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Abstract Background CCN1 plays a crucial role in the modulation of cardiovascular diseases. However, whether CCN1 genetic variants are involved in the susceptibility of ACS remains unknown. Hence, the present study investigates the association between CCN1 polymorphisms and ACS among Han and Uygur populations in Xinjiang, China. Results In this case-control study, 1234 Han (547 ACS patients and 687 controls) and 932 Uygur (471 ACS patients and 461 controls) were genotyped using SNPscanTM for three single-nucleotide polymorphisms (SNPs, rs6576776, rs954353, and rs3753794) of the human CCN1 gene. In the Uygur population, we found that the detected frequencies of the C allele (25.3% vs. 18.3%, P
- Subjects :
- Acute coronary syndrome
CCN1
Polymorphism
Genotyping
Haplotype
Genetics
QH426-470
Subjects
Details
- Language :
- English
- ISSN :
- 16015223
- Volume :
- 158
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Hereditas
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fb5d169291cd4781a0472788af4111ab
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s41065-021-00180-2