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Green synthesis of novel isatin thioketal derivatives under solvent-free conditions
- Source :
- Green Chemistry Letters and Reviews, Vol 10, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- Taylor & Francis Group, 2017.
-
Abstract
- A new series of spiro[[1,3]dithiolane-2,3′-indolines]-2′-one derivatives was synthesized using Michael addition reaction of spiro[[1,3]dithiolane-2,3′-indolin]-2′-one to various α,β-unsaturated esters as well as direct alkylation of this compound with alkyl dihalides. Michael reaction of spiro[[1,3]dithiolane-2,3′-indolin]-2′-one and α,β-unsaturated esters produced related Michael adduct in the presence of tetrabutylammonium bromide and base 1,4-diazabicyclo[2.2.2]octane in good to excellent yields at 80°C under solvent-free conditions. Also, direct alkylation of spiro[[1,3]dithiolane-2,3′-indolin]-2′-one by dihaloalkanes in the presence of base K2CO3 afforded the corresponding products in good yields under the same conditions.
Details
- Language :
- English
- ISSN :
- 17518253 and 17517192
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Green Chemistry Letters and Reviews
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fb8b15a34878490dac42b74075f911dd
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/17518253.2016.1250958