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Disposition Kinetics of Taxanes in Peritoneal Dissemination

Authors :
Ken'ichi Miyamoto
Tsutomu Shimada
Kazuki Sawamoto
Yoshimichi Sai
Yutaka Yonemura
Source :
Gastroenterology Research and Practice, Vol 2012 (2012)
Publication Year :
2012
Publisher :
Hindawi Limited, 2012.

Abstract

Treatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal dissemination. They are administered as micellar preparations, Taxol and Taxotere, which consist of paclitaxel in Cremophor EL (crEL) and docetaxel in Polysorbate-80 (PS-80), respectively. In this paper we review the disposition kinetics of taxane anticancer drugs after intraperitoneal administration in peritoneal dissemination patients and animal models and also discuss the effect of the surfactant vehicle on the behavior of taxanes.

Details

Language :
English
ISSN :
16876121 and 1687630X
Volume :
2012
Database :
Directory of Open Access Journals
Journal :
Gastroenterology Research and Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.fb8e02e1980e42d7842b6347b00f05d8
Document Type :
article
Full Text :
https://doi.org/10.1155/2012/963403