Back to Search Start Over

PPAR-Mediated Toxicology and Applied Pharmacology

Authors :
Yue Xi
Yunhui Zhang
Sirui Zhu
Yuping Luo
Pengfei Xu
Zhiying Huang
Source :
Cells, Vol 9, Iss 2, p 352 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs fibrates and thiazolidinediones (TZDs). Despite their potent pharmacological activities, PPARs are reported to be involved in agent- and pollutant-induced multiple organ toxicity or protective effects against toxicity. A better understanding of the protective and the detrimental role of PPARs will help to preserve efficacy of the PPAR modulators but diminish adverse effects. The present review summarizes and critiques current findings related to PPAR-mediated types of toxicity and protective effects against toxicity for a systematic understanding of PPARs in toxicology and applied pharmacology.

Details

Language :
English
ISSN :
20734409
Volume :
9
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.fbcc254afe847e5bf451ce11e83281a
Document Type :
article
Full Text :
https://doi.org/10.3390/cells9020352