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Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment

Authors :
Krisztián Pamlényi
Géza Regdon
Dániel Nemes
Ferenc Fenyvesi
Ildikó Bácskay
Katalin Kristó
Source :
Pharmaceutics, Vol 14, Iss 8, p 1633 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully formulated buccal mucoadhesive polymer films, which contained cetirizine-hydrochloride (CTZ) as the API. The present study focused on investigating the stability and permeability of the prepared films. The stability of the films was studied with an accelerated stability test. During the stability test, thickness, breaking hardness and in vitro mucoadhesivity were analysed. Furthermore, the interactions were studied with FT-IR spectroscopy, and the changes in the amount of the API were also monitored. Cytotoxicity and cell line permeability studies were carried out on TR 146 buccal cells. Compositions that can preserve more than 85% of the API after 6 months were found. Most of the compositions had a high cell viability of more than 50%. Citric acid (CA) decreased the stability and reduced every physical parameter of the films. However, cell line studies showed that the permeability of the films was enhanced. In our work, we successfully formulated CTZ-containing buccal films with adequate stability, high cell viability and appropriate absorption properties.

Details

Language :
English
ISSN :
19994923
Volume :
14
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.fc839fa2c1114ba88696d5a70760008e
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics14081633