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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Authors :
William J. Young
Jeffrey Haessler
Jan-Walter Benjamins
Linda Repetto
Jie Yao
Aaron Isaacs
Andrew R. Harper
Julia Ramirez
Sophie Garnier
Stefan van Duijvenboden
Antoine R. Baldassari
Maria Pina Concas
ThuyVy Duong
Luisa Foco
Jonas L. Isaksen
Hao Mei
Raymond Noordam
Casia Nursyifa
Anne Richmond
Meddly L. Santolalla
Colleen M. Sitlani
Negin Soroush
Sébastien Thériault
Stella Trompet
Stefanie Aeschbacher
Fariba Ahmadizar
Alvaro Alonso
Jennifer A. Brody
Archie Campbell
Adolfo Correa
Dawood Darbar
Antonio De Luca
Jean-François Deleuze
Christina Ellervik
Christian Fuchsberger
Anuj Goel
Christopher Grace
Xiuqing Guo
Torben Hansen
Susan R. Heckbert
Rebecca D. Jackson
Jan A. Kors
Maria Fernanda Lima-Costa
Allan Linneberg
Peter W. Macfarlane
Alanna C. Morrison
Pau Navarro
David J. Porteous
Peter P. Pramstaller
Alexander P. Reiner
Lorenz Risch
Ulrich Schotten
Xia Shen
Gianfranco Sinagra
Elsayed Z. Soliman
Monika Stoll
Eduardo Tarazona-Santos
Andrew Tinker
Katerina Trajanoska
Eric Villard
Helen R. Warren
Eric A. Whitsel
Kerri L. Wiggins
Dan E. Arking
Christy L. Avery
David Conen
Giorgia Girotto
Niels Grarup
Caroline Hayward
J.Wouter Jukema
Dennis O. Mook-Kanamori
Morten Salling Olesen
Sandosh Padmanabhan
Bruce M. Psaty
Cristian Pattaro
Antonio Luiz P. Ribeiro
Jerome I. Rotter
Bruno H. Stricker
Pim van der Harst
Cornelia M. van Duijn
Niek Verweij
James G. Wilson
Michele Orini
Philippe Charron
Hugh Watkins
Charles Kooperberg
Henry J. Lin
James F. Wilson
Jørgen K. Kanters
Nona Sotoodehnia
Borbala Mifsud
Pier D. Lambiase
Larisa G. Tereshchenko
Patricia B. Munroe
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

The spatial and frontal QRS-T angles are electrocardiographic (ECG) predictors for arrhythmia. This work used genetic analyses to identify associated loci and pathways, and explore their relationships with other ECG traits and cardiovascular disease.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.fca92a55c441c48a99162ccb2f3205
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36997-w