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A case of refractory anti-MDA5-positive amyopathic dermatomyositis successfully treated with upadacitinib

Authors :
Xin Huang
Guiying Zhang
Shuaihantian Luo
Source :
Journal of Dermatological Treatment, Vol 35, Iss 1 (2024)
Publication Year :
2024
Publisher :
Taylor & Francis Group, 2024.

Abstract

Purpose: Amyopathic dermatomyositis (ADM) is a rare, idiopathic, connective tissue disease and melanoma differentiation-associated protein 5 (MDA5) antibody-positive ADM is more treatment-resistant, especially in patients with interstitial lung disease (ILD). The purpose of this article is to report a case of anti-MDA5-positive ADM successfully treated with JAK inhibitor Upadacitinib.Materials and methods: A 35-year-old Chinese woman presented with recurrent itchy erythema on her face and scalp for 4 years. Upon examination, there were heliotrope erythema and eyelid edema, reddish rash on neck and scalp. Biopsy of the lesions was consistent with DM and a line blot assay confirmed the presence of anti-MDA5 antibodies. This patient was treated with oral Upadacitinib at a dosage of 30 mg daily.Results: After 6 weeks of treatment, she achieved complete clinical remission with no reported side effects or instances of relapse. The antibody titer of anti-MDA5 was also decreased.Conclusions: Upadacitinib may be a potential drug candidate in patients with treatment-resistant ADM, especially in cases with refractory cutaneous conditions.

Details

Language :
English
ISSN :
09546634 and 14711753
Volume :
35
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Dermatological Treatment
Publication Type :
Academic Journal
Accession number :
edsdoj.fcbc69fc31124951990e626cdf69f2ac
Document Type :
article
Full Text :
https://doi.org/10.1080/09546634.2024.2391445