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Risk factor analysis and molecular epidemiology of respiratory adenovirus infections among children in northern Taiwan, 2009–2013
- Source :
- Journal of Microbiology, Immunology and Infection, Vol 50, Iss 4, Pp 418-426 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Background/Purpose: Respiratory infections caused by human adenoviruses (HAdV) are worldwide, and have significantly increased recently in Taiwan. This study aimed to clarify the molecular epidemiology and risk factors of HAdV severe infections and pneumonia among Taiwanese children. Methods: Patients with HAdV infections and hospitalized in a medical center between 2009 and 2013 were divided into severe or nonsevere HAdV infections based on whether or not they received intensive care. HAdV pneumonia was identified for comparison. The HAdV genotype was determined by sequencing the partial hexon and fiber genes. The nucleotide sequences were compared by phylogenetic analysis. Results: The 176 patients (97 boys, 79 girls) had a median age of 3.7 years. The HAdV infections circulated year-round. HAdV B3 (54.5%) was the most common genotype, followed by HAdV C2 (21%), HAdV E4 (8%), and HAdV B7 (6.8%). Thirty-two patients needed intensive care. In multivariate analysis, the risk factors for severe HAdV infections were underlying neurologic diseases [odds ratio (OR): 164.9; p
- Subjects :
- adenovirus
children
genotypes
pneumonia
severe infection
Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 16841182
- Volume :
- 50
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Microbiology, Immunology and Infection
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fcce8977536b44d2aff26d8af56bd273
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jmii.2015.08.006