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Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can

Authors :
Álvaro Tamayo-Velasco
María Jesús Peñarrubia Ponce
Francisco Javier Álvarez
Hugo Gonzalo-Benito
Ignacio de la Fuente
Sonia Pérez-González
Lucía Rico
María Teresa Jiménez García
Alba Sánchez Rodríguez
Milagros Hijas Villaizan
Marta Martín-Fernández
Carlos Dueñas
Esther Gómez-Sánchez
María Heredia-Rodríguez
Óscar Gorgojo-Galindo
Itziar Fernández
Lourdes del Río
Irene Carnicero-Frutos
María Fe Muñoz-Moreno
Eduardo Tamayo
David Bernardo
Pedro Martínez-Paz
Source :
Frontiers in Immunology, Vol 12 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains unclear in COVID-19 patients. In this sense, we prospectively recruited 108 COVID-19 patients between March and April 2020 and divided according to ABO blood group. For the analysis of 45 cytokines, plasma samples were collected in the time of admission to hospital ward or intensive care unit and at the sixth day after hospital admission. The results show that there was a risk of more than two times lower of mechanical ventilation or death in patients with blood group O (log rank: p = 0.042). At first time, all statistically significant cytokine levels, except from hepatocyte growth factor, were higher in O blood group patients meanwhile the second time showed a significant drop, between 20% and 40%. In contrast, A/B/AB group presented a maintenance of cytokine levels during time. Hepatocyte growth factor showed a significant association with intubation or mortality risk in non-O blood group patients (OR: 4.229, 95% CI (2.064–8.665), p < 0.001) and also was the only one bad prognosis biomarker in O blood group patients (OR: 8.852, 95% CI (1.540–50.878), p = 0.015). Therefore, higher cytokine levels in O blood group are associated with a better outcome than A/B/AB group in COVID-19 patients.

Details

Language :
English
ISSN :
16643224
Volume :
12
Database :
Directory of Open Access Journals
Journal :
Frontiers in Immunology
Publication Type :
Academic Journal
Accession number :
edsdoj.fcebb21b8ee547e0b64da58405cc63a5
Document Type :
article
Full Text :
https://doi.org/10.3389/fimmu.2021.726283