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Angiopoietin-2 as a prognostic biomarker in septic adult patients: a systemic review and meta-analysis
- Source :
- Annals of Intensive Care, Vol 14, Iss 1, Pp 1-11 (2024)
- Publication Year :
- 2024
- Publisher :
- SpringerOpen, 2024.
-
Abstract
- Abstract Background The impairment of endothelial function represents a key pathophysiological mechanism in the development of sepsis. This research aimed to evaluate the prognostic significance of angiopoietin-2 (Ang-2), an endothelial biomarker, in predicting mortality in sepsis patients. Methods Chinese and English studies were systematically retrieved in PubMed, Cochrane Library, Embase, WanFang, CNKI, CQVIP, and CBM databases up to July 16, 2023. We conducted a study selection established upon predefined inclusion and exclusion criteria and used the Newcastle-Ottawa scale (NOS) to assess its quality. We extracted available data from the included studies for data analysis. Results The final inclusion comprised 33 studies with 4703 participants. According to the NOS, one study was of medium quality, while the rest were of high quality. In comparison to survivors, the levels of Ang-2 in non-survivors were markedly elevated [standardized mean difference (SMD) = 1.08, 95% confidence intervals (CI) 0.68–1.49, P
Details
- Language :
- English
- ISSN :
- 21105820
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Annals of Intensive Care
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fd1562f71421a8cded55ae6240914
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13613-024-01393-0