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Angiopoietin-2 as a prognostic biomarker in septic adult patients: a systemic review and meta-analysis

Authors :
Mengke Zhuo
Sifeng Fu
Yawen Chi
Xinghua Li
Sirui Li
Xiaochun Ma
Xu Li
Source :
Annals of Intensive Care, Vol 14, Iss 1, Pp 1-11 (2024)
Publication Year :
2024
Publisher :
SpringerOpen, 2024.

Abstract

Abstract Background The impairment of endothelial function represents a key pathophysiological mechanism in the development of sepsis. This research aimed to evaluate the prognostic significance of angiopoietin-2 (Ang-2), an endothelial biomarker, in predicting mortality in sepsis patients. Methods Chinese and English studies were systematically retrieved in PubMed, Cochrane Library, Embase, WanFang, CNKI, CQVIP, and CBM databases up to July 16, 2023. We conducted a study selection established upon predefined inclusion and exclusion criteria and used the Newcastle-Ottawa scale (NOS) to assess its quality. We extracted available data from the included studies for data analysis. Results The final inclusion comprised 33 studies with 4703 participants. According to the NOS, one study was of medium quality, while the rest were of high quality. In comparison to survivors, the levels of Ang-2 in non-survivors were markedly elevated [standardized mean difference (SMD) = 1.08, 95% confidence intervals (CI) 0.68–1.49, P

Details

Language :
English
ISSN :
21105820
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Annals of Intensive Care
Publication Type :
Academic Journal
Accession number :
edsdoj.fd1562f71421a8cded55ae6240914
Document Type :
article
Full Text :
https://doi.org/10.1186/s13613-024-01393-0