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Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species

Authors :
Francesca Guzzo
Alexandra G. Durán
Cinzia Sanna
Rosangela Marasco
Nicola Molfetta
Elisabetta Buommino
Antonio Fiorentino
Brigida D’Abrosca
Source :
Molecules, Vol 27, Iss 20, p 7109 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against Staphylococcus species, bioactive fractions of Myrtus communis L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (1–4), three of them gallomyrtucommulones G–H (1,2), and myrtucommulonoside (4) isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (5), myricetin-3-O-glycosides (6,7) were determined based on the spectroscopic evidence including 1D-/2D-NMR and HR-MS spectrometry. Enriched fractions as well as pure compounds were tested for their antimicrobial activity by broth micro-dilution assay against Staphylococcus epidermidis and S. aureus. Results reported herein demonstrated that gallomyrtucommulone G (1) showed a selective antimicrobial activity against both S. aureus strains (ATCC 29213 and 43300) until 16 μg/mL while gallomyrtucommulone D (3) showed the best growth inhibition value at 64 μg/mL.

Details

Language :
English
ISSN :
14203049
Volume :
27
Issue :
20
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.fd6459cb080741f0b07782c7a661760d
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules27207109