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Adalimumab Serum Concentrations, Clinical and Endoscopic Disease Activity in Crohn’s Disease: A Cross-Sectional Multicentric Latin American Study

Authors :
Letícia Rodrigues de Souza
Daniela Oliveira Magro
Fábio Vieira Teixeira
Rogério Serafim Parra
Eron Fábio Miranda
Omar Féres
Rogério Saad-Hossne
Giedre Soares Prates Herrerias
Renato Mitsunori Nisihara
Claudio Saddy Rodrigues Coy
Ligia Yukie Sassaki
Paulo Gustavo Kotze
Source :
Pharmaceutics, Vol 15, Iss 2, p 586 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Despite some variability in ideal serum Adalimumab (ADA) concentrations, there is increasing evidence that higher concentrations of anti-TNF-α agents can be associated with sustained efficacy, and low or undetectable levels may lead to loss of response. This study aims to correlate serum ADA concentrations with clinical and endoscopic activity in patients with Crohn’s disease (CD). A cross-sectional and multicentric study was performed with patients with CD, who used ADA for at least 24 weeks. Patients were allocated into groups according to the presence of clinical or endoscopic disease activity. Serum ADA concentrations were measured and compared between groups. Overall, 89 patients were included. A total of 27 patients had clinically active CD and 62 were in clinical remission. Forty patients had endoscopic disease activity and 49 were in endoscopic remission. The mean serum ADA concentration was 10.2 μg/mL in patients with clinically active CD and 14.3 μg/mL in patients in clinical remission (p = 0.395). The mean serum ADA concentration in patients with endoscopic activity was 11.3 μg/mL as compared to 14.5 μg/mL in those with endoscopic remission (p = 0.566). There was no difference between serum ADA concentrations regarding clinical or endoscopic activity in CD, as compared to patients in remission

Details

Language :
English
ISSN :
19994923
Volume :
15
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.fd86a0b7d00d46ebac688a385fb4ebe1
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics15020586