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Necrostatin-1: a promising compound for neurological disorders

Authors :
Ke-qian Chen
Shu-zhi Wang
Hai-bo Lei
Xiang Liu
Source :
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Necrostatin-1, a small molecular alkaloid, was identified as an inhibitor of necroptosis in 2005. Investigating the fundamental mechanism of Necrostatin-1 and its role in various diseases is of great significance for scientific and clinical research. Accumulating evidence suggests that Necrostatin-1 plays a crucial role in numerous neurological disorders. This review aims to provide a comprehensive overview of the potential functions of Necrostatin-1 in various neurological disorders, offering valuable insights for future research.

Details

Language :
English
ISSN :
16625102
Volume :
18
Database :
Directory of Open Access Journals
Journal :
Frontiers in Cellular Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.fd907e1e8f8b4b849c586fb0043cc608
Document Type :
article
Full Text :
https://doi.org/10.3389/fncel.2024.1408364