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The Rarity in the Rarity: Presentation of Three Cases of Cutaneous Carcinosarcoma with Clinical and Histopathological Insights

Authors :
Gerardo Cazzato
Anna Colagrande
Valentina Caputo
Giuseppe Ingravallo
Eliano Cascardi
Francesco Fortarezza
Emanuela Bonoldi
Franco Rongioletti
Source :
Dermatopathology, Vol 11, Iss 3, Pp 209-217 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

A cutaneous carcinosarcoma (cCS) is a rare and aggressive skin cancer characterized by both carcinomatous (epithelial) and sarcomatous (mesenchymal) components, making it a biphasic tumor. Despite its occurrence in various organs, a cCS is exceptionally rare in the skin, predominantly affecting older males. The etiology of a cCS is unclear, but it may originate from a single progenitor cell capable of dual differentiation or from a collision of carcinoma and sarcoma cells. Clinically, a cCS presents as a rapidly growing, painful, ulcerated nodule or plaque on sun-exposed skin, with a high risk of local invasion and metastasis. Histopathologically, a cCS includes various epithelial components, such as squamous cell carcinoma and basal cell carcinoma, along with undifferentiated sarcomatous components resembling atypical fibroxanthoma. The tumor may also exhibit heterologous differentiation like angiosarcomatous or rhabdomyosarcomatous features. We present three cases of a cCS, highlighting their clinical and histological characteristics and comparing them with previously reported cases. Understanding a cCS is complicated by its rarity and diverse presentation, emphasizing the need for further research to elucidate its pathogenesis and optimal management.

Details

Language :
English
ISSN :
22963529
Volume :
11
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Dermatopathology
Publication Type :
Academic Journal
Accession number :
edsdoj.fe1b7c146e1423e9be98c05155fd806
Document Type :
article
Full Text :
https://doi.org/10.3390/dermatopathology11030022