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Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.

Authors :
Inca H R Hundscheid
Dirk H S M Schellekens
Joep Grootjans
Marcel Den Dulk
Ronald M Van Dam
Geerard L Beets
Wim A Buurman
Kaatje Lenaerts
Joep P M Derikx
Cornelis H C Dejong
Source :
PLoS ONE, Vol 16, Iss 6, p e0253506 (2021)
Publication Year :
2021
Publisher :
Public Library of Science (PLoS), 2021.

Abstract

BackgroundWe developed a jejunal and colonic experimental human ischemia-reperfusion (IR) model to study pathophysiological intestinal IR mechanisms and potential new intestinal ischemia biomarkers. Our objective was to evaluate the safety of these IR models by comparing patients undergoing surgery with and without in vivo intestinal IR.MethodsA retrospective study was performed comparing complication rates and severity, based on the Clavien-Dindo classification system, in patients undergoing pancreatoduodenectomy with (n = 10) and without (n = 20 matched controls) jejunal IR or colorectal surgery with (n = 10) and without (n = 20 matched controls) colon IR. Secondary outcome parameters were operative time, blood loss, 90-day mortality and length of hospital stay.ResultsFollowing pancreatic surgery, 63% of the patients experienced one or more postoperative complications. There was no significant difference in incidence or severity of complications between patients undergoing pancreatic surgery with (70%) or without (60%, P = 0.7) jejunal IR. Following colorectal surgery, 60% of the patients experienced one or more postoperative complication. Complication rate and severity were similar in patients with (50%) and without (65%, P = 0.46) colonic IR. Operative time, amount of blood loss, postoperative C-reactive protein, length of hospital stay or mortality were equal in both intervention and control groups for jejunal and colon IR.ConclusionThis study showed that human experimental intestinal IR models are safe in patients undergoing pancreatic or colorectal surgery.

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
16
Issue :
6
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.fe55f9ae98a648f184efc56f55753e21
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0253506