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Mechanism of Coronary Microcirculation Obstruction after Acute Myocardial Infarction and Cardioprotective Strategies

Authors :
Yuyu Li
Jiaqi Yu
Yuan Wang
Source :
Reviews in Cardiovascular Medicine, Vol 25, Iss 10, p 367 (2024)
Publication Year :
2024
Publisher :
IMR Press, 2024.

Abstract

ST-segment elevation myocardial infarction patients are best treated with emergency percutaneous coronary intervention (PCI), while coronary microvascular dysfunction and obstruction (CMVO) are indicated by the absence or slowing of antegrade epicardial flow on angiography, resulting in suboptimal myocardial perfusion despite the lack of mechanical vascular obstruction. CMVO occurs in up to half of patients who undergo PCI for the first time and is associated with poor outcomes. This review summarizes the complex mechanisms leading to CMVO and elaborates on the changes observed at the organism, tissue, organ, cellular, and molecular levels. It also describes the current diagnostic methods and comprehensive treatment methods for CMVO.

Details

Language :
English
ISSN :
15306550
Volume :
25
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Reviews in Cardiovascular Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.fef40518b24dd9ae0daa448e4dbea0
Document Type :
article
Full Text :
https://doi.org/10.31083/j.rcm2510367