Back to Search Start Over

Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke

Authors :
Rebecca I. Sienel
Uta Mamrak
Janina Biller
Stefan Roth
Andreas Zellner
Tipparat Parakaw
Rayomand S. Khambata
Arthur Liesz
Christof Haffner
Amrita Ahluwalia
Burcu F. Seker
Nikolaus Plesnila
Source :
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Ischemic stroke is a major global health issue and characterized by acute vascular dysfunction and subsequent neuroinflammation. However, the relationship between these processes remains elusive. In the current study, we investigated whether alleviating vascular dysfunction by restoring vascular nitric oxide (NO) reduces post-stroke inflammation. Mice were subjected to experimental stroke and received inhaled NO (iNO; 50 ppm) after reperfusion. iNO normalized vascular cyclic guanosine monophosphate (cGMP) levels, reduced the elevated expression of intercellular adhesion molecule-1 (ICAM-1), and returned leukocyte adhesion to baseline levels. Reduction of vascular pathology significantly reduced the inflammatory cytokines interleukin-1β (Il-1β), interleukin-6 (Il-6), and tumor necrosis factor-α (TNF-α), within the brain parenchyma. These findings suggest that vascular dysfunction is responsible for leukocyte adhesion and that these processes drive parenchymal inflammation. Reversing vascular dysfunction may therefore emerge as a novel approach to diminish neuroinflammation after ischemic stroke and possibly other ischemic disorders.

Details

Language :
English
ISSN :
17422094
Volume :
20
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Neuroinflammation
Publication Type :
Academic Journal
Accession number :
edsdoj.ff1eeded54441de8fcfefccd3e1e390
Document Type :
article
Full Text :
https://doi.org/10.1186/s12974-023-02988-3