Different Immune Responses in Dangerous O Blood Donors

Authors :: shaghayegh Arabi
Mostafa Moghadam
Vida Maleki
Ali Akbar Pourfatholah
Afsaneh Aghaie
Source :: Iranian Journal of Pathology, Vol 15, Iss 1, Pp 34-40 (2020)
Publication Year :: 2020
Publisher :: Iranian Society of Pathology, 2020.
Abstract: Background & Objective:Dangerous O is very important to transfusion medicine and there has been reports by Food and Drug Administration (FDA) regarding some death relating incidences. As high iso-antibody production is closely associated with different immune reactions, a survey on the different immune response of dangerous O donors can lead to understanding their immune response profile. Objectives were to assess different immune responses in dangerous O cases.Methods:Two groups of donors were selected after performing titration as a high titer (>512) and non-high titer (