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Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats

Authors :
Ye jin Yang
Jun-Ho Song
Ju-Hye Yang
Min Jung Kim
Kwang Youn Kim
Jin-Kyoung Kim
Yeung Bea Jin
Woo Hyun Kim
Suk Kim
Ki-Rim Kim
Kwang Il Park
Hu-Jang Lee
Source :
Molecules, Vol 28, Iss 2, p 849 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Periodontitis is caused by pathogens in the oral cavity. It is a chronic infectious disease that causes symptoms including gingival bleeding and tooth loss resulting from the destruction of periodontal tissues coupled with inflammation. Dendropanax morbiferus H.Lév (DM) is a natural product that exhibits various biological activities with few side effects. In this study, the potential of DM leaf hot-water extracts (DMWE) as a treatment for periodontitis was determined and its anti-oxidant and anti-inflammatory effects were evaluated. Compounds in DMWE were identified by high-performance liquid chromatography (HPLC) and nitric oxide (NO) and prostaglandin E2 (PGE2) production was measured in RAW 264.7 cells. We measured the gingival index and gingival sulcus depth, and micro-CT was performed in vivo using a ligature-induced periodontitis rat model, which is similar to human periodontitis. The DMWE-treated group exhibited a decrease in cytokine concentration and relieved the gingival index and gingival sulcus depth compared with the periodontitis-induced control group. In addition, micro-CT and histological analysis revealed that DMWE exhibited anti-inflammatory effects and improved alveolar bone loss in periodontitis-induced rats. These findings suggest that DMWE has excellent anti-oxidant and anti-inflammatory effects that protect and prevent periodontal tissue damage and tooth loss caused by the inflammatory response.

Details

Language :
English
ISSN :
14203049
Volume :
28
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.ffe4745e5afd45a8a81ae6f8d1769d8c
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules28020849