Epigenetics of Stress and Stress Disorders

Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigeneticmechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through theevaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stressdisorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understandingstress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range ofrecent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developmentsin noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physicaleffects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods ordevelopment and across the life span. The book concludes by looking at possible transgenerational stress-inducedepigenetic alterations on future offspring and important areas of research for public health, along with the potential forepigenetic therapeutics or'epidrugs. - Examines the epigenetics of stress, trauma, and related stress disorders - Connects new research to clinical practice and highlights implications for patient care, drug discovery, andpublic health - Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigeneticalterations - Features chapter contributions from international experts in the field