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Recent Advances in Bacterial Biofilm Studies - Formation, Regulation, and Eradication in Human Infections

Authors :
Liang Wang
Bing Gu
Li Zhang
Zuobin Zhu
Liang Wang
Bing Gu
Li Zhang
Zuobin Zhu
Publication Year :
2024

Abstract

Bacterial biofilm is a complex structure with diverse bacterial cells in a highly organized and ordered group within a matrix of extracellular polymeric substances they produce. Microbes attach to surfaces to develop biofilms, a sophisticated process regulated by factors such as nutritional status and biotic/abiotic surface features. An established biofilm structure mainly comprises bacterial cells, proteins, nucleic acid, and exo-polysaccharides that are extracellular macromolecules excreted as tightly bound layers in microbes, providing a perfect niche for bacteria to exchange genetic material between cells. In addition, bacterial cells in the matrix also communicate via quorum sensing, which greatly impacts biofilm processes. Under clinical circumstances, bacterial biofilm shows great resistance to antibiotics, disinfectants, and body defense systems, making it difficult for clinicians to eradicate and facilitate many infectious disease processes, leading to chronic infections of patients with long-term hospitalization and high mortality rates. Therefore, it is very important to understand the recent advances in forming, regulating, and eradicating biofilms in human infections to better prevent, control, and treat biofilm infections in humans. Written by an international team of basic and clinical researchers, the chapters of this book provide novel insights and advanced knowledge for life science researchers, clinical researchers, doctors, and other interested readers on some of the latest developments in biofilms.

Subjects

Subjects :
Bacteria
Biofilms

Details

Language :
English
ISBNs :
9781803567082 and 9781803567167
Database :
eBook Index
Journal :
Recent Advances in Bacterial Biofilm Studies - Formation, Regulation, and Eradication in Human Infections
Publication Type :
eBook
Accession number :
4007582