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Case Series: Severe meibomian gland loss in polycystic ovarian syndrome patients on estrogen-progesterone therapy: A case series [version 2; peer review: 2 approved]
- Source :
- F1000Research. 12:1154
- Publication Year :
- 2024
- Publisher :
- London, UK: F1000 Research Limited, 2024.
-
Abstract
- Purpose: To report the ocular surface and meibomian gland changes in polycystic ovarian syndrome (PCOS) women taking hormone supplementation. Methods: Case series. Results: Three women (27 ± 11 years) already diagnosed with PCOS presented with dry eye symptoms (mean OSDI, 37.5) for a mean duration of 13 months and were taking hormonal supplements for a mean duration of 60 ± 11 months. The hormonal supplements included oral estrogen (n=3), oral progesterone (n=3), antiandrogen cyproterone (n=1) and isotretinoin (n=1). Ocular surface evaluation revealed mean NIBUT of 9.9 ± 1.6 seconds and mean TMH of 0.27 ± 0.05 mm, assessed non-invasively using Oculus keratograph 5M (K5M). Meibography (K5M) showed near total loss of all meibomian glands (n=8/12 eyelids) with residual ghost glands in all four eyelids of two patients, and gland shortening alone in one patient. The gland morphology did not change following intense thermal pulsation treatment or cessation of hormonal therapy. Conclusions: Near-total irreversible meibomian gland loss was seen in two young PCOS women taking hormonal supplements. Collaboration between ophthalmologists and gynecologists is advisable for early detection and better understanding of dry eye disease (DED) progression in these patients.
Details
- ISSN :
- 20461402
- Volume :
- 12
- Database :
- F1000Research
- Journal :
- F1000Research
- Notes :
- Revised Amendments from Version 1 In the new version, we have made the changes as requested by the reviewer. The title now has a case series, as the paper described three cases. The abstract and results section added details on the treatment given to the patients. Minor corrections in the syntax have been made as reviewers suggested., , [version 2; peer review: 2 approved]
- Publication Type :
- Academic Journal
- Accession number :
- edsfor.10.12688.f1000research.139229.2
- Document Type :
- other
- Full Text :
- https://doi.org/10.12688/f1000research.139229.2