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Assessment of serum testosterone, estradiol, and progesterone levels in female patients with acne vulgaris [version 3; peer review: 1 approved, 1 not approved]
- Source :
- F1000Research. 11:23
- Publication Year :
- 2022
- Publisher :
- London, UK: F1000 Research Limited, 2022.
-
Abstract
- Introduction: Acne is a chronic inflammatory disorder of the pilosebaceous unit with differential pathogenesis. To elucidate the roles of hormones in acne pathogenesis, we conducted a study to evaluate the serum testosterone, estradiol, progesterone levels in women with acne vulgaris. Methods: We conducted a cross-sectional descriptive study, and 175 women with acne vulgaris were examined; their serum estradiol, progesterone, testosterone were analyzed by chemiluminescence technique and compared with the healthy control group. Results: Increased serum hormone levels in women with acne vulgaris were accounted for 29.7%, and hyperandrogenism was accounted for 16.0% of cases. We found significant differences in testosterone levels (mean value, 55.67±25.56 versus 38.37±10.16 ng/dL, p0.05) levels. Moreover, we did not find the relationship between serum hormone levels and the severity of acne vulgaris. Conclusion: This study showed that the female acne vulgaris patients may have high serum testosterone levels and low serum estradiol levels compared with those of female controls. However, hormone alterations had no correlation with the acne grades.
- Subjects :
- Research Article
Articles
Acne vulgaris
hormone
Subjects
Details
- ISSN :
- 20461402
- Volume :
- 11
- Database :
- F1000Research
- Journal :
- F1000Research
- Notes :
- Revised Amendments from Version 2 Exclusion criteria were described in more detail. PCOS was ruled out by clinical manifestations and hormone tests. The discussion part also analyzed more information., , [version 3; peer review: 1 approved, 1 not approved]
- Publication Type :
- Academic Journal
- Accession number :
- edsfor.10.12688.f1000research.75617.3
- Document Type :
- research-article
- Full Text :
- https://doi.org/10.12688/f1000research.75617.3