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Recent advances on Candida albicans biology and virulence [version 1; referees: 2 approved]

Authors :
Adnane Sellam
Malcolm Whiteway
Author Affiliations :
<relatesTo>1</relatesTo>Infectious Diseases Research Centre-CRI, CHU de Québec Research Center (CHUQ), Université Laval, Quebec City, Quebec, Canada<br /><relatesTo>2</relatesTo>Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada<br /><relatesTo>3</relatesTo>Department of Biology, Concordia University, Montreal, Quebec, Canada
Source :
F1000Research. 5:F1000 Faculty Rev-2582
Publication Year :
2016
Publisher :
London, UK: F1000 Research Limited, 2016.

Abstract

Candida albicans is an important human fungal pathogen, in terms of both its clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, and increasing resistance to the front-line therapeutics, demonstrating a clear need for new antifungal drugs. Understanding the biology of this pathogen is an important prerequisite for identifying new drug targets for antifungal therapeutics. In this review, we highlight some recent developments that help us to understand how virulence traits are regulated at the molecular level, in addition to technical advances that improve the ability of genome editing in C. albicans.

Subjects

Subjects :
Review
Articles
Cellular Microbiology & Pathogenesis
Control of Gene Expression
Environmental Microbiology
Genomics
Medical Microbiology
Microbial Evolution & Genomics
Microbial Growth & Development
Microbial Physiology & Metabolism
Candida albicans
antifungal drugs
C. albicans
genome editing
virulence

Details

ISSN :
20461402
Volume :
5
Database :
F1000Research
Journal :
F1000Research
Notes :
Editorial Note on the Review Process F1000 Faculty Reviews are commissioned from members of the prestigious F1000 Faculty and are edited as a service to readers. In order to make these reviews as comprehensive and accessible as possible, the referees provide input before publication and only the final, revised version is published. The referees who approved the final version are listed with their names and affiliations but without their reports on earlier versions (any comments will already have been addressed in the published version). The referees who approved this article are: Guilhem Janbon, Department of Mycology, Unit of Fungal Biology and Pathogenicity, Institut Pasteur, France INRA, Paris, France No competing interests were disclosed. Carol Munro, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, MRC Center for Medical Mycology, University of Aberdeen, Aberdeen, UK No competing interests were disclosed., , [version 1; referees: 2 approved]
Publication Type :
Academic Journal
Accession number :
edsfor.10.12688.f1000research.9617.1
Document Type :
review
Full Text :
https://doi.org/10.12688/f1000research.9617.1
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