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Mechanism of ubiquitin recognition by the CUE domain of Vps9p

Authors :
Prag, Gali
Misra, Saurav
Jones, Eudora A.
Ghirlando, Rodolfo
Davies, Brian A.
Horazdovsky, Bruce F.
Hurley, James H.
Source :
Cell. May 30, 2003, Vol. 113 Issue 5, 609-620
Publication Year :
2003

Abstract

The CUE domain of the Vps9p sorting protein binds to monoubiquitin. The two binding surfaces of the CUE monomer are opposite to each other and cannot bind a ubiquitin molecule simultaneously. However, dimerization facilitates both sides to bind a monoubiquitin molecule.

Subjects

Subjects :
Ubiquitin -- Physiological aspects
Protein binding -- Physiological aspects
Proteins
Structure-activity relationships (Biochemistry) -- Analysis
Biological sciences

Details

Language :
English
ISSN :
00928674
Volume :
113
Issue :
5
Database :
Gale General OneFile
Journal :
Cell
Publication Type :
Academic Journal
Accession number :
edsgcl.104616326

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