Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes

Research elucidates catalysis of poly-ubiquitin chain formation, from a structural point of view, facilitated by the Uev.Ubc13 heterodimer. Data indicate that poly-ubiquitin chain formation involves interactions between components of Lys(sup)63-linked poly-ubiquitin conjugation machinery. Furthermore, results discuss affinity, stoichiometry, specificity, and binding kinetics between the acceptor ubiquitin and the reactants.