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EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
- Source :
- Cell. Nov 26, 2003, Vol. 115 Issue 5, 523-535
- Publication Year :
- 2003
-
Abstract
- Research demonstrates that EMSY protein binds BRCA2 within exon 3 region, which is deleted in cancer. It can silence the activation potential of BRCA2 exon 3 and is localized to sites of repair, following DNA damage, on chromosome 11q13.5 involved in breast and ovarian cancer. Furthermore, EMSY gene is amplified in sporadic breast cancer and advanced ovarian cancer.
Details
- Language :
- English
- ISSN :
- 00928674
- Volume :
- 115
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.111900087