Pharmacogenetic profiling in azathioprine treatment: TPMT, ITPA, and MTHFR polymorphisms and toxicity

Authors :: Ansari, A.
Arenas, M.
Lindsay, J.
Morris, D.
Greenfield, S.
Raoof, S.
Fong, F.
Fairbanks, L.
Marinaki, T.
Duley, J.
Sanderson, J.
Soon, S.L.
Source :: Gut. April 2004, Vol. 53 Issue 4, , A105, p1 p.
Publication Year :: 2004
Abstract: Background: The activity of various of the enzymes affecting the metabolism of azathioprine are affected by allelic polymorphisms. Of these, thiopurine methyl transferase is the best known, but inosine triphosphate [...]

Subjects :: Azathioprine -- Health aspects -- Research
Genetic polymorphisms -- Research -- Health aspects
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