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Modification of 1-substituents in the 2-azabicyclo[2.1.1]hexane ring system; approaches to potential nicotinic acetylcholine receptor lingands from 2,4-methanoproline derivatives
- Source :
- Journal of Organic Chemistry. April 2, 2004, Vol. 69 Issue 7, 9348-9355
- Publication Year :
- 2004
-
Abstract
- The construction of novel derivatives has been made possible because of a nucleophilic substitution at a methylene attached to the bridgehead (1-) position of the 2-azabicyclo[2.1.1]hexane ring system. This provides access to epibatidine analogues, which contains heterocyclic substituents, and to homologation at the 1-position.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 69
- Issue :
- 7
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.119208278