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An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr Kinase from mycobacterium tuberculosis

Authors :
Molle, Virginie
Kremer, Laurent
Girard-Blanc, Christine
Besra, Gurdyal S.
Cozzone, Alain J.
Prost, Jean-Francois
Source :
Biochemistry. Dec 30, 2003, Vol. 42 Issue 51, 15300-15309
Publication Year :
2003

Abstract

Protein PknH possesses an autokinase activity and belongs to large STPK family found in macobacterium tuberculosis. EmbR possesses an FHA domain, a newly described phosphoprotein recognition domain, which plays an essential role in PknH-EmbR interaction and phosphorylation of EmbR by PknH.

Subjects

Subjects :
Biochemistry -- Research
Phosphorylation -- Research
Mycobacterium tuberculosis -- Research
Phosphoproteins -- Research
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00062960
Volume :
42
Issue :
51
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.121259242

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