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Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope

Authors :
Darbha, Ramalakshmi
Phogat, Sanjay
Labrijn, Aran F.
Shu, Yuuei
Gu, Yijun
Andrykovitch, Michelle
Zhang, Mei-Yun
Pantophlet, Ralph
Martin, Loic
Claudio, Vita
Burton, Dennis R.
Dimitrov, Dimiter S.
Ji, Xinhua
Source :
Biochemistry. Feb 17, 2004, Vol. 43 Issue 6, 1410-1417
Publication Year :
2004

Abstract

The human monoclonal antibody Fab X5 neutralizes a broad range of HIV-1 primary isolates. It is reported that in the asymmetric unit there are two crystallographically independent Fab fragments.

Details

Language :
English
ISSN :
00062960
Volume :
43
Issue :
6
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.122567785