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Importance of clustered 2'-0-(2-Aminoethyl) residues for the gene targeting activity of triple helix-forming oligonucleotides
- Source :
- Biochemistry. Feb 10, 2004, Vol. 43 Issue 5, 1343-1351
- Publication Year :
- 2004
-
Abstract
- The development in living mammalian cells of triple helix-forming oligonucleotides as gene targeting reagents is studied. The results show that for optimal bioactivity, the 2'-0-[2-Aminoethyl] residues should be clustered rather than dispersed.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 43
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.122868059